Respiratory Trials·org

Infection control · Positioning to prevent pneumonia

van Nieuwenhoven 2006 randomised trial

Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia

van Nieuwenhoven 2006 trial design and results
Design Multicentre randomised study
Treatment Targeted backrest elevation of 45 degrees
Control Standard supine positioning
Population 221 mechanically ventilated patients: 109 supine and 112 semirecumbent
Follow-up ICU stay
Primary endpoint Incidence of ventilator-associated pneumonia
Result The 45-degree target was never reached. Average elevations achieved were 9.8 degrees in the supine group and 28 degrees in the semirecumbent group, and the achieved difference in position did not reduce ventilator-associated pneumonia.
Secondary endpoints Achieved backrest elevation, mortality, length of stay

The targeted backrest elevation of 45 degrees for semirecumbent positioning was not reached in the conditions of the present randomized study.

The trial authors, in the published abstract

How it has aged

An honest implementation failure that is more informative than a clean result would have been. It does not refute Drakulovic 1999 so much as show that the intervention cannot be delivered as specified — a distinction worth remembering whenever a care bundle specifies an angle.

Publications

Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study

van Nieuwenhoven CA, Vandenbroucke-Grauls C, van Tiel FH, et al. Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study. Crit Care Med 2006 Feb;34(2):396-402.

  • Target 45 degrees never achieved; mean 28 degrees delivered
  • No reduction in ventilator-associated pneumonia at the elevation actually achieved