Topic
Sedation, analgesia & delirium
Sedation depth, agent choice, and delirium prevention.
No trial records summarised for this topic yet.
Key references
Guidelines, standards and reviews for this topic.
- Delirium in the ICU
- Ely EW, Shintani A, Truman B, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 2004 Apr 14;291(14):1753-62. PMID 15082703
- Guidelines
- Lewis K, Balas MC, Stollings JL, et al. A Focused Update to the Clinical Practice Guidelines for the Prevention and Management of Pain, Anxiety, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. Crit Care Med 2025 Mar 1;53(3):e711-e727. PMID 39982143
- Devlin JW, Skrobik Y, Gélinas C, et al. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. Crit Care Med 2018 Sep;46(9):e825-e873. PMID 30113379
Studies not yet summarised
On the reading list for this topic and awaiting a full record. Listed here so nothing is hidden.
- Comparison Between Administration Methods
- Mehta S, Burry L, Cook D, et al. Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA 2012 Nov 21;308(19):1985-92. PMID 23180503
- Kress JP, Pohlman AS, O'Connor MF, et al. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000 May 18;342(20):1471-7. PMID 10816184
- Comparison Between Agents
- Walsh TS, Parker RA, Aitken LM, et al. Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial. JAMA 2025 Jul 1;334(1):32-45. PMID 40388916
- Hughes CG, Mailloux PT, Devlin JW, et al. Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis. N Engl J Med 2021 Apr 15;384(15):1424-1436. PMID 33528922
- Shehabi Y, Howe BD, Bellomo R, et al. Early Sedation with Dexmedetomidine in Critically Ill Patients. N Engl J Med 2019 Jun 27;380(26):2506-2517. PMID 31112380
- Riker RR, Shehabi Y, Bokesch PM, et al. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA 2009 Feb 4;301(5):489-99. PMID 19188334
- Delirium in the ICU
- Andersen-Ranberg NC, Poulsen LM, Perner A, et al. Haloperidol for the Treatment of Delirium in ICU Patients. N Engl J Med 2022 Dec 29;387(26):2425-2435. PMID 36286254
- Girard TD, Exline MC, Carson SS, et al. Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness. N Engl J Med 2018 Dec 27;379(26):2506-2516. PMID 30346242
- Pandharipande PP, Girard TD, Jackson JC, et al. Long-term cognitive impairment after critical illness. N Engl J Med 2013 Oct 3;369(14):1306-16. PMID 24088092