Topic
Sepsis & septic shock
Fluids, vasopressors, steroids, and the rise and fall of protocolised care.
No trial records summarised for this topic yet.
Key references
Guidelines, standards and reviews for this topic.
- Albumin for Fluid Resuscitation
- Callum J, Skubas NJ, Bathla A, et al. Use of Intravenous Albumin: A Guideline From the International Collaboration for Transfusion Medicine Guidelines. Chest 2024 Aug;166(2):321-338. PMID 38447639
- Guidelines
- Prescott HC, Antonelli M, Alhazzani W, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026. Intensive Care Med 2026 May;52(5):863-936. PMID 41870560
- Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016 Feb 23;315(8):801-10. PMID 26903338
- Hemodynamic Monitoring
- Vincent JL, Joosten A, Saugel B. Hemodynamic Monitoring and Support. Crit Care Med 2021 Oct 1;49(10):1638-1650. PMID 34269718
Studies not yet summarised
On the reading list for this topic and awaiting a full record. Listed here so nothing is hidden.
- Antibiotics
- Dark P, Hossain A, McAuley DF, et al. Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial. JAMA 2025 Feb 25;333(8):682-693. PMID 39652885
- Daneman N, Rishu A, Pinto R, et al. Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections. N Engl J Med 2025 Mar 13;392(11):1065-1078. PMID 39565030
- Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006 Jun;34(6):1589-96. PMID 16625125
- Early resuscitation
- Hernandez G, Ospina-Tascón GA, Kattan E, et al. Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial. JAMA 2025 Dec 9;334(22):1988-1999. PMID 41159835
- Shapiro NI, Douglas IS, Brower RG, et al. Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. N Engl J Med 2023 Feb 9;388(6):499-510. PMID 36688507
- Meyhoff TS, Hjortrup PB, Wetterslev J, et al. Restriction of Intravenous Fluid in ICU Patients with Septic Shock. N Engl J Med 2022 Jun 30;386(26):2459-2470. PMID 35709019
- Mouncey PR, Osborn TM, Power GS, et al. Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 2015 Apr 2;372(14):1301-11. PMID 25776532
- Yealy DM, Kellum JA, Huang DT, et al. A randomized trial of protocol-based care for early septic shock. N Engl J Med 2014 May 1;370(18):1683-93. PMID 24635773
- Peake SL, Delaney A, Bailey M, et al. Goal-directed resuscitation for patients with early septic shock. N Engl J Med 2014 Oct 16;371(16):1496-506. PMID 25272316
- Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001 Nov 8;345(19):1368-77. PMID 11794169
- Hemodynamic Monitoring
- Muller G, Contou D, Ehrmann S, et al. Deferring Arterial Catheterization in Critically Ill Patients with Shock. N Engl J Med 2025 Nov 13;393(19):1875-1888. PMID 41159885
- Steroids
- Venkatesh B, Finfer S, Cohen J, et al. Adjunctive Glucocorticoid Therapy in Patients with Septic Shock. N Engl J Med 2018 Mar 1;378(9):797-808. PMID 29347874
- Annane D, Renault A, Brun-Buisson C, et al. Hydrocortisone plus Fludrocortisone for Adults with Septic Shock. N Engl J Med 2018 Mar 1;378(9):809-818. PMID 29490185
- Vasopressors
- Khanna A, English SW, Wang XS, et al. Angiotensin II for the Treatment of Vasodilatory Shock. N Engl J Med 2017 Aug 3;377(5):419-430. PMID 28528561
- Russell JA, Walley KR, Singer J, et al. Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 2008 Feb 28;358(9):877-87. PMID 18305265