Topic
Neurology in critical care
Cardiac arrest, traumatic brain injury, stroke, and neuroprognostication.
No trial records summarised for this topic yet.
Key references
Guidelines, standards and reviews for this topic.
- Acute hemorrhagic stroke
- Greenberg SM, Ziai WC, Cordonnier C, et al. 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association. Stroke 2022 Jul;53(7):e282-e361. PMID 35579034
- Coma/Anoxic Brain Injury
- Hirsch KG, Amorim E, Coppler PJ, et al. Part 11: Post-Cardiac Arrest Care: 2025 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2025 Oct 21;152(16_suppl_2):S673-S718. PMID 41122894
- Rajajee V, Muehlschlegel S, Wartenberg KE, et al. Guidelines for Neuroprognostication in Comatose Adult Survivors of Cardiac Arrest. Neurocrit Care 2023 Jun;38(3):533-563. PMID 36949360
- Sandroni C, D'Arrigo S, Nolan JP. Prognostication after cardiac arrest. Crit Care 2018 Jun 5;22(1):150. PMID 29871657
- Primary neuromuscular disease
- Khan A, Frazer-Green L, Amin R, et al. Respiratory Management of Patients With Neuromuscular Weakness: An American College of Chest Physicians Clinical Practice Guideline and Expert Panel Report. Chest 2023 Aug;164(2):394-413. PMID 36921894
Studies not yet summarised
On the reading list for this topic and awaiting a full record. Listed here so nothing is hidden.
- Acute Ischemic Stroke - Thrombectomy
- Qiu Z, Li F, Sang H, et al. Intravenous Tenecteplase before Thrombectomy in Stroke. N Engl J Med 2025 Jul 10;393(2):139-150. PMID 40396577
- Nogueira RG, Jadhav AP, Haussen DC, et al. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct. N Engl J Med 2018 Jan 4;378(1):11-21. PMID 29129157
- Acute Ischemic Stroke - Thrombolytic Therapy
- Zhou Y, He Y, Campbell BCV, et al. Alteplase for Acute Ischemic Stroke at 4.5 to 24 Hours: The HOPE Randomized Clinical Trial. JAMA 2025 Sep 2;334(9):788-797. PMID 40773205
- Ma H, Campbell BCV, Parsons MW, et al. Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke. N Engl J Med 2019 May 9;380(19):1795-1803. PMID 31067369
- Thomalla G, Simonsen CZ, Boutitie F, et al. MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset. N Engl J Med 2018 Aug 16;379(7):611-622. PMID 29766770
- Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008 Sep 25;359(13):1317-29. PMID 18815396
- Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995 Dec 14;333(24):1581-7. PMID 7477192
- Acute hemorrhagic stroke
- Qureshi AI, Palesch YY, Barsan WG, et al. Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage. N Engl J Med 2016 Sep 15;375(11):1033-43. PMID 27276234
- Coma/Anoxic Brain Injury
- Jabre P, Bougouin W, Dumas F, et al. Early Identification of Patients With Out-of-Hospital Cardiac Arrest With No Chance of Survival and Consideration for Organ Donation. Ann Intern Med 2016 Dec 6;165(11):770-778. PMID 27618681
- Coplin WM, Pierson DJ, Cooley KD, et al. Implications of extubation delay in brain-injured patients meeting standard weaning criteria. Am J Respir Crit Care Med 2000 May;161(5):1530-6. PMID 10806150
- Subarachnoid Hemorrhage
- Pickard JD, Murray GD, Illingworth R, et al. Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial. BMJ 1989 Mar 11;298(6674):636-42. PMID 2496789
- Therapeutic hypothermia following cardiac arrest
- Dankiewicz J, Cronberg T, Lilja G, et al. Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest. N Engl J Med 2021 Jun 17;384(24):2283-2294. PMID 34133859
- Transfusion in acute brain injury
- English SW, Delaney A, Fergusson DA, et al. Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage. N Engl J Med 2025 Mar 13;392(11):1079-1088. PMID 39655786
- Turgeon AF, Fergusson DA, Clayton L, et al. Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury. N Engl J Med 2024 Aug 22;391(8):722-735. PMID 38869931
- Taccone FS, Rynkowski CB, Møller K, et al. Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial. JAMA 2024 Nov 19;332(19):1623-1633. PMID 39382241