Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients
Drakulovic 1999 trial design and results
Design
Randomised controlled trial
Treatment
Semirecumbent position at 45 degrees
Control
Supine position
Population
86 mechanically ventilated patients
Follow-up
ICU stay
Primary endpoint
Clinically suspected nosocomial pneumonia
Result
Clinically suspected nosocomial pneumonia occurred in 3 of 39 (8%) semirecumbent patients versus 16 of 47 (34%) supine patients (95% CI for the difference 10.0 to 42.0). The effect was greatest in patients receiving enteral nutrition.
Secondary endpoints
Microbiologically confirmed pneumonia, interaction with enteral feeding
The semirecumbent body position reduces frequency and risk of nosocomial pneumonia, especially in patients who receive enteral nutrition.
The trial authors, in the published abstract
How it has aged
The basis for head-of-bed elevation in every ventilator care bundle, on 86 patients. van Nieuwenhoven 2006 then showed that 45 degrees is almost never actually achieved in practice, which makes the real-world benefit far less certain than the bundle implies.
Publications
Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial
Drakulovic MB, Torres A, Bauer TT, et al. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet 1999 Nov 27;354(9193):1851-8.