Procedures · Preoxygenation before intubation
Noninvasive Ventilation for Preoxygenation during Emergency Intubation
| Design | Multicentre randomised controlled trial |
|---|---|
| Treatment | Preoxygenation with non-invasive ventilation |
| Control | Preoxygenation with an oxygen mask |
| Population | 1301 critically ill adults undergoing tracheal intubation |
| Follow-up | Intubation episode |
| Primary endpoint | Hypoxaemia during intubation, oxygen saturation below 85% |
| Result | Hypoxaemia occurred in 57 of 624 (9.1%) with non-invasive ventilation versus 118 of 637 (18.5%) with an oxygen mask. |
| Secondary endpoints | Lowest oxygen saturation, cardiac arrest, aspiration |
Among critically ill adults undergoing tracheal intubation, preoxygenation with noninvasive ventilation resulted in a lower incidence of hypoxemia during intubation than preoxygenation with an oxygen mask.
The trial authors, in the published abstract
A halving of a dangerous, common event with equipment already at the bedside. Together with DEVICE and PreVent it has rebuilt the ICU intubation checklist around the minutes before the laryngoscope is picked up.
Gibbs KW, Semler MW, Driver BE, et al. Noninvasive Ventilation for Preoxygenation during Emergency Intubation. N Engl J Med 2024 Jun 20;390(23):2165-2177.