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Pulmonary rehabilitation · Delivering rehabilitation differently

Holland 2017 randomised trial

Home-based rehabilitation for COPD using minimal resources

Holland 2017 trial design and results
Design Randomised controlled equivalence trial
Treatment Home-based pulmonary rehabilitation delivered with minimal resources
Control Centre-based pulmonary rehabilitation
Population 166 participants with COPD: 86 centre-based and 80 home-based
Follow-up 12 months
Primary endpoint Change in six-minute walk distance at end of rehabilitation
Result Home-based rehabilitation was non-inferior for six-minute walk distance at end of rehabilitation, with the confidence interval not excluding superiority (mean difference favouring home 18.6 m, 95% CI -3.3 to 40.7). At 12 months the interval did not exclude inferiority (-5.1 m, -29.2 to 18.9).
Secondary endpoints Quality of life, symptoms, longer-term maintenance, completion rates

This home-based pulmonary rehabilitation model, delivered with minimal resources, produced short-term clinical outcomes that were equivalent to centre-based pulmonary rehabilitation.

The trial authors, in the published abstract

How it has aged

Attacks the access problem directly: most eligible patients never reach a centre-based programme, so equivalence at home is a substantial practical gain. Bourne 2023 later showed the same for long-term maintenance and readmissions.

Publications

Home-based rehabilitation for COPD using minimal resources: a randomised, controlled equivalence trial

Holland AE, Mahal A, Hill CJ, et al. Home-based rehabilitation for COPD using minimal resources: a randomised, controlled equivalence trial. Thorax 2017 Jan;72(1):57-65.

  • Non-inferior six-minute walk distance versus centre-based rehabilitation
  • Delivered with minimal resources
  • Short-term outcomes only