A Pragmatic Trial of E-Cigarettes, Incentives, and Drugs for Smoking Cessation
Halpern 2018 trial design and results
Design
Pragmatic randomised controlled trial
Treatment
Free cessation aids, free e-cigarettes, or free cessation aids plus financial incentives
Control
Usual care: information and motivational text messages
Population
6006 smokers employed by a large company
Follow-up
6 months
Primary endpoint
Sustained smoking abstinence through 6 months
Result
Sustained abstinence was 0.1% with usual care, 0.5% with free cessation aids, 1.0% with free e-cigarettes and higher again when financial incentives were added to free cessation aids. Among participants who actively engaged with the trial, rates were four to six times higher with similar relative effectiveness.
Secondary endpoints
Abstinence in the engaged cohort, uptake of cessation aids
In this pragmatic trial of smoking cessation, financial incentives added to free cessation aids resulted in a higher rate of sustained smoking abstinence than free cessation aids alone. Among smokers who received usual care, the addition of free cessation aids or e-cigarettes did not provide a benefit.
The trial authors, in the published abstract
How it has aged
Look at the absolute numbers: 0.1% to 1.0% abstinence. Offering unmotivated smokers free products barely moves anything — the effect lives in engagement, and money buys engagement. The contrast with TEC, where every participant had actively sought help and abstinence reached 18%, is the whole lesson.
Publications
A Pragmatic Trial of E-Cigarettes, Incentives, and Drugs for Smoking Cessation
Halpern SD, Harhay MO, Saulsgiver K, et al. A Pragmatic Trial of E-Cigarettes, Incentives, and Drugs for Smoking Cessation. N Engl J Med 2018 Jun 14;378(24):2302-2310.
Financial incentives added to free cessation aids improved sustained abstinence
Free cessation aids or e-cigarettes alone gave no benefit over usual care
Absolute abstinence rates were very low, from 0.1% to a few percent