223 sleepy patients with mild to moderate obstructive sleep apnoea
Follow-up
8 weeks
Primary endpoint
Functional Outcomes of Sleep Questionnaire score
Result
Adjusted mean change in the Functional Outcomes of Sleep Questionnaire total score after the first 8-week period was 0.89 with CPAP (n=113) versus -0.06 with sham (n=110), p=0.006 — an effect size of 0.41 (95% CI 0.14 to 0.67).
Secondary endpoints
Epworth Sleepiness Scale, quality of life
Continuous positive airway pressure treatment improves the functional outcome of sleepy patients with mild and moderate obstructive sleep apnoea.
The trial authors, in the published abstract
How it has aged
Defines the indication that the cardiovascular trials never threatened. SAVE and Barbe 2012 deliberately enrolled non-sleepy patients and found no event reduction; CATNAP enrolled sleepy ones and found they felt and functioned better. Symptoms are the reason to treat.
Publications
Continuous positive airway pressure treatment of sleepy patients with milder obstructive sleep apnea: results of the CPAP Apnea Trial North American Program (CATNAP) randomized clinical trial
Weaver TE, Mancini C, Maislin G, et al. Continuous positive airway pressure treatment of sleepy patients with milder obstructive sleep apnea: results of the CPAP Apnea Trial North American Program (CATNAP) randomized clinical trial. Am J Respir Crit Care Med 2012 Oct 1;186(7):677-83.
Improved functional outcomes versus sham CPAP
Benefit demonstrated in mild and moderate disease, in symptomatic patients